Lawrence C Layman Selected Research

Idiopathic Hypogonadotropic Hypogonadism

4/2011	Nasal embryonic LHRH factor (NELF) mutations in patients with normosmic hypogonadotropic hypogonadism and Kallmann syndrome.
10/2010	WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
1/2010	Genotype and phenotype of patients with gonadotropin-releasing hormone receptor mutations.
10/2008	Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
6/2008	The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.
1/2008	Clinical manifestations of impaired GnRH neuron development and function.
6/2007	Hypogonadotropic hypogonadism.
10/2005	The prevalence of gonadotropin-releasing hormone receptor mutations in a large cohort of patients with hypogonadotropic hypogonadism.
12/2002	Clinical phenotype and infertility treatment in a male with hypogonadotropic hypogonadism due to mutations Ala129Asp/Arg262Gln of the gonadotropin-releasing hormone receptor.

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Lawrence C Layman Research Topics

Disease

9	Idiopathic Hypogonadotropic Hypogonadism 04/2011 - 12/2002
8	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2021 - 12/2002
6	Kallmann Syndrome (Kallmann's Syndrome) 01/2021 - 01/2008
5	Infertility (Sterility) 01/2021 - 12/2002
5	Intellectual Disability (Idiocy) 01/2020 - 01/2014
3	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 10/2017 - 07/2013
3	Delayed Puberty 05/2015 - 10/2012
3	Insulin Resistance 01/2015 - 07/2013
3	Azoospermia 03/2013 - 08/2002
2	Leiomyoma (Uterine Fibroids) 01/2017 - 04/2015
2	Oligospermia (Oligozoospermia) 03/2009 - 12/2002
1	Primary Ovarian Insufficiency 12/2020
1	Ovarian Cysts (Ovarian Cyst) 01/2020
1	Gender Dysphoria 12/2019
1	Endometriosis 10/2017
1	Ovarian Hyperstimulation Syndrome 10/2017
1	Mullerian aplasia 10/2017
1	Pituitary Neoplasms (Pituitary Adenoma) 01/2017
1	Sotos Syndrome 11/2016
1	Autistic Disorder (Autism) 01/2016
1	Epilepsy (Aura) 01/2016
1	Hyperinsulinism (Hyperinsulinemia) 12/2014
1	Hyperglycemia 12/2014
1	Reinfection 01/2014
1	Adenoma (Adenomas) 03/2013
1	Gonadoblastoma 10/2012
1	Germ Cell and Embryonal Neoplasms (Germ Cell Tumor) 10/2012
1	Triple X syndrome 10/2012
1	Craniofacial Abnormalities 07/2012
1	Coloboma (Colobomas) 10/2011
1	CHARGE Syndrome 10/2011
1	Hematocolpos 11/2010
1	Infections 09/2009
1	Inborn Genetic Diseases (Disease, Hereditary) 06/2008
1	Anosmia 01/2008
1	Hemorrhage 10/2007

Drug/Important Bio-Agent (IBA)

7	Gonadotropin-Releasing Hormone (GnRH)FDA Link 01/2021 - 01/2008
5	Proteins (Proteins, Gene)FDA Link 01/2020 - 10/2008
4	GonadotropinsIBA 12/2020 - 12/2002
3	LHRH Receptors (Gonadotropin-Releasing Hormone Receptor)IBA 01/2010 - 12/2002
2	Estrogens (Estrogen)FDA Link 12/2019 - 07/2013
2	Hormones (Hormone)IBA 10/2017 - 06/2008
2	Histone MethyltransferasesIBA 11/2016 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 12/2014 - 07/2013
2	DNA (Deoxyribonucleic Acid)IBA 10/2012 - 04/2005
2	Testosterone (Sustanon)FDA Link 03/2009 - 06/2007
1	GlucocorticoidsIBA 12/2020
1	MineralsIBA 01/2020
1	SteroidsIBA 10/2017
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 01/2017
1	BerberineIBA 01/2017
1	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 11/2016
1	Glycine Receptors (Glycine Receptor)IBA 08/2016
1	ChromatinIBA 01/2016
1	Histone DemethylasesIBA 01/2016
1	Mediator ComplexIBA 04/2015
1	MicroRNAs (MicroRNA)IBA 01/2015
1	Protein Isoforms (Isoforms)IBA 12/2014
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 12/2014
1	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 01/2014
1	Estrogen ReceptorsIBA 07/2013
1	LigandsIBA 03/2013
1	AldosteroneIBA 03/2013
1	Complement System Proteins (Complement)IBA 10/2012
1	DNA HelicasesIBA 10/2011
1	Transcription Factors (Transcription Factor)IBA 10/2010
1	Pituitary GonadotropinsIBA 01/2008
1	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 03/2007
1	beta Subunit Follicle Stimulating Hormone (Follicle-Stimulating Hormone, beta Subunit)IBA 08/2002

Therapy/Procedure

3	Therapeutics 12/2020 - 12/2002
1	Sutures (Suture) 11/2010
1	Laparotomy 09/2009
1	Ligation 06/2008
1	Hysterectomy 10/2007